The patient was a 48-year-old female admitted to the hospital with “progressive abdominal distension for 2 months, 5 years after ovarian cancer surgery”. After admission, she found that her intestinal obstruction was gradually worsening, and imaging suggested ovarian cancer with pelvic metastasis and a large mass in the pelvic floor compressing the rectum, causing obstruction. The patient had been treated with multiple chemotherapy regimens and was considered to control the tumor and relieve the obstruction, so preoperative interventional embolization of the tumor-related vessels, intraoperative radiofrequency ablation of the giant pelvic tumor, 125I particle implantation at or near the edge of the tumor to maximize coverage of the tumor tissue and treat or control the tumor, and biopsy of the pelvic mass to send chemotherapy drugs and molecular targeting drugs for screening in preparation for subsequent treatment were chosen. Finally, transverse colon fistula was completed to relieve intestinal obstruction. Therefore, on 2011-12-21, we performed abdominal exploration, pelvic mass biopsy, radiofrequency ablation therapy, 125I particle implantation at the tumor margin, and transverse colostomy under general anesthesia. A small amount of light yellow ascites was found on the exploration, and suspicious metastatic nodules on the surface of the left and right lobes of the liver, the larger one was about 3*2.5cm in size; there was no obvious abnormality in the stomach wall; there was no abnormality in the appearance of the small intestine, and local adhesions were obvious; there was no obvious abnormality in the transverse colon, and the pelvic floor mass was about 10*5*4.5cm in size and fixed, which had involved the bladder, sigmoid colon and rectum were invaded and covered the surface of the mass. Therefore, some specimens were excised and sent for genetic monitoring of chemotherapy drug sensitivity and tolerance. The radiofrequency ablation needle was placed and the radiofrequency ablation treatment was completed step by step. 31 125I particles were implanted at the edges of the mass and near the cavernous organs by progressive puncture and needle placement. During the procedure, a small amount of bleeding was stopped by compression. A transverse incision was made in the right upper abdomen, and the right part of the transverse colon was lifted to complete the transverse colostomy. Intraoperative bleeding was about 50 ml, and blood gas analysis showed Hb:78g/L, so 2U of blood pressure was transfused, and 400 ml of plasma was transfused to replenish coagulation factors. the patient’s vital signs were stable during the operation, and he was directly sent to the ICU ward for further monitoring and support. The patient resumed diet soon after the operation and was discharged as scheduled. This case is an advanced tumor combined with intestinal obstruction, which has undergone multiple times and multiple regimens of chemotherapy, while the tumor still recurred uncontrollably. We chose to treat or control the tumor by preoperative intervention, intraoperative tumor radiofrequency ablation therapy, tumor margin 125I particle implantation and other treatment means, while performing tumor biopsy to send chemotherapeutic drugs and molecular targeting drug screening for the preparation of subsequent treatment, reflecting the whole idea of individualized tumor treatment.