According to the standard of World Health Organization, tumor pain is divided into mild, moderate and severe pains, and three steps of pain relief drugs can be used according to the patients’ pain degree, generally NSAIDs, weak opioid painkillers and strong opioid painkillers. 1. If there is a need for medication, you can choose to use NSAIDs to help patients with pain, NSAIDs commonly used are ibuprofen, diclofenac sodium, acetaminophen, indomethacin suppositories and so on. However, NSAIDs should not be taken for a long time to prevent damage to the gastrointestinal tract, liver and kidney functions of patients; 2. Weak opioid analgesics: when the pain has affected normal life and cannot well ensure rest, weak opioid analgesics can be used at this time, such as codeine, dihydrocodeine, tramadol and other drugs, and with NSAIDs, together to help patients with pain; 3. Strong opioid analgesics: when The patient’s pain is extremely unbearable and cannot be relieved by the above drugs, strong opioid analgesics can be used, such as morphine, hydromorphone, methadone, oxycodone, pethidine, fentanyl, etc. Such drugs do not have a capping effect, and most patients can relieve pain after taking them. In addition, when patients have neuropathic pain, they can be used together with anticonvulsant drugs such as carbamazepine. It can also be combined with sedative drugs to increase the pain-relieving effect, and patients are advised to take the drugs while ensuring their own nutritional supply to enhance the body’s resistance and tissue repair ability to help the pain be relieved as soon as possible and improve the patient’s quality of life. When applying more painkillers, we should pay attention to their adverse effects, such as respiratory depression, constipation and other common adverse effects, and give timely symptomatic intervention.