Hepatoportal cholangiocellular carcinoma needs to be treated with surgery, chemotherapy and targeted therapy according to specific conditions. 1. Surgery: it is the most effective means to treat hilar cholangiocellular carcinoma. Hepatoportal cholangiocellular carcinoma has a special location and the malignant degree of hepatoportal cholangiocellular carcinoma is often high, so only a few people are eligible for surgery, and the surgical methods include radical resection, jejunostomy of left (right) intrahepatic bile duct, bile duct stent implantation, and in-situ liver transplantation. 2. Chemotherapy: If it is difficult to remove the tumor lesions cleanly or there are extensive metastatic foci, chemotherapy is usually used to alleviate the condition and control the further deterioration of the tumor, so as to prolong the survival period and improve the prognosis, and the chemotherapeutic drugs include cisplatin, fluorouracil and so on. 3. Targeted therapy: When hepatoportal cholangiocellular carcinoma is in advanced stage, bile can be drained through biliary stent implantation, and targeted therapy can be used to control the condition, and the targeted drugs include lenvatinib, etc. In addition, when the tumor invades to a larger extent, chemotherapy is usually used to alleviate the condition and control the further deterioration of the tumor. In addition, surgery combined with chemotherapy or targeted therapy can be adopted when the tumor invades to a larger extent, which can improve the survival rate. When hilar cholangiocellular carcinoma occurs, standardized treatment should be carried out under the guidance of doctors to avoid delaying the condition.