The onset of action of corkscrew usually does not last more than 30 minutes. Kefir works by hypertonicity, softening the stool and stimulating bowel contractions to facilitate bowel movements. It also has a lubricating effect, preventing dry stools from damaging the intestines and facilitating defecation. Keflex is mostly used for constipation and is contraindicated for those who are allergic to the drug. With the use of Keflex, there may be a strong contraction of local tissues, causing transient local ischemia and triggering inflammation. Care should be taken to handle the catheter opening when using it to avoid abrasions to the anus or intestines. The drug is administered directly from the anus into the intestine. The onset of action of the Keswick is fast, in 5-10 minutes; slower, not more than 30 minutes. You need to use the medication under the supervision of a doctor and avoid blind use of the drug to avoid adverse reactions.