Ankylosis generally refers to ankylosing spondylitis, which cannot usually be prevented from being passed on to the next generation, but is not present in all children. The cause of ankylosing spondylitis is unknown, and is considered to be related to infection, immunity, and genetics. Ankylosing spondylitis is mainly caused by the HLA-B27 susceptibility gene, and studies have shown that first-degree relatives of ankylosing spondylitis have a higher chance of developing the disease, and there is currently no way to avoid passing on ankylosing spondylitis to the next generation. For patients with a family history of AS, it is important to avoid prolonged exposure to damp and cold environments or frequent use of cold water to avoid triggering AS. In addition, avoid prolonged sedentary behavior, because prolonged sedentary behavior and inactivity of the spine may also induce ankylosing spondylitis. For patients with a family history of ankylosing spondylitis, it is important to correct poor sitting or standing postures, pay attention to keeping warm, and go to the hospital for regular checkups. Patients with ankylosing spondylitis are advised to seek timely medical treatment and choose appropriate measures under the guidance of the doctor.