There is no one better between metoprolol and bisoprolol, the specific medication needs to follow the doctor’s instructions. Metoprolol and Bisoprolol are both beta-blockers for angina pectoris, post myocardial infarction, tachyarrhythmia, etc. Asthma, COPD, bradycardia are all prohibited, which can easily cause heart rate slowing, abdominal pain, dizziness and other adverse reactions. The difference is mainly as follows. 1. Effectiveness: the former is about 10 times more effective than the latter. 2. Bioavailability: the bioavailability of Bisoprolol is about 90%, and that of Metoprolol is about 30%~40%. 3. Onset of action: Metoprolol has a rapid onset of action, peaking in about 1.5 hours, while Bisoprolol peaks after 4 hours of oral administration. 4. Half-life: Half-life is the time of action in the body, Metoprolol about 4 hours, Bisoprolol about 11 hours. 5. Metabolic pathway: Both drugs are metabolized by the liver and kidneys, but metoprolol is almost completely metabolized by the liver. Both need to be used under professional medical supervision.