In general, a colonoscopic biopsy suggesting low-grade intraepithelial neoplasia is a benign lesion. It occurs for a number of reasons, which may be related to inflammatory stimulation of the intestinal tract or may be related to familial inheritance. The tumor will develop low-grade intraepithelial neoplasia, high-grade intraepithelial neoplasia, and then may become precancerous as it continues to develop. For adenomas or polyps with low-grade intraepithelial neoplasia, they can be surgically removed directly under colonoscopy, with regular follow-up and observation after surgery. There is no need to worry too much about low-grade intraepithelial neoplasia suggested by colonoscopy biopsy, but it should not be completely ignored. It is recommended to review the colonoscopy regularly to avoid further development. Normally, we should pay attention to the reasonable diet, supplement some vitamin-rich foods, and take more dietary fiber.