Urine protein a plus and a minus in medicine is called weak positive, in normal urine, urine protein can be weak positive, but must be reviewed again, may be caused by physiological factors, may be caused by pathological factors, such as interstitial nephritis or glomerulonephritis and so on. 1. It may be caused by physiological factors, such as strenuous exercise, fever or chills, etc., you can drink a lot of water, and review to see if the protein in the urine test is still present. 2. It may also be caused by pathological factors, such as interstitial nephritis or glomerulonephritis. It is recommended that the patient go to the hospital in time for examination to rule out the cause of the disease, so as not to delay the condition. (1) Interstitial nephritis: interstitial nephritis is generally caused by bacterial and microbial infections, blood system diseases, metabolic diseases and other factors caused by interstitial damage to the renal tubules, which is generally manifested as nausea, vomiting, nocturia, arthralgia and other symptoms. (2) Glomerulonephritis: Glomerulonephritis is generally caused by immune system diseases, infections, underlying chronic diseases and other diseases, and generally manifested as proteinuria, hematuria, edema and other symptoms. Through symptomatic treatment, it can improve the condition and cure the disease. When the urine protein is weakly positive, it is recommended that the patient review and feasible 24 hours of quantitative urine protein examination, the urine specimen should be careful to follow the prescribed procedures to avoid the impact on the results of the examination.