Jaundice in advanced stage of gallbladder cancer is usually due to bile duct obstruction, which can usually be treated by resection surgery, percutaneous puncture biliary drainage and medication. 1. Excision surgery: when gallbladder cancer is in advanced stage, the mass presses on bile ducts, which will easily cause bile duct obstruction and lead to poor bile excretion, and then jaundice occurs. At this time, the swollen gallbladder can be surgically removed to relieve the symptoms. 2. Percutaneous transluminal biliary drainage: When jaundice occurs due to bile duct obstruction, patients can also be treated with percutaneous transluminal biliary drainage to relieve the symptoms of jaundice. 3. Drug treatment: patients with jaundice in advanced stage of gallbladder cancer can take drugs such as polyene phosphatidylcholine capsule, reduced glutathione tablets, compound glycyrrhizin capsule and so on according to doctor’s instruction to reduce jaundice. When jaundice occurs in the advanced stage of gallbladder cancer, it is suggested that patients should follow the doctor’s instruction to choose appropriate methods for treatment in order to achieve the effect of relieving symptoms.