The drugs that can be used after malignant tumor bone metastasis are: analgesic drugs, bisphosphonates, disulfiram and so on. 1. Analgesic drugs: malignant tumor bone metastasis will cause persistent severe pain at the metastatic site, so reasonable analgesic treatment is very important to improve the quality of patient’s survival. According to the degree of pain, we can choose ibuprofen, tramadol, morphine, aminophenol hydrocodone and other analgesic drugs with different intensity. 2. Bisphosphonates: Bisphosphonates are a class of drugs that can inhibit osteoclast activity, which can effectively inhibit the osteolytic reaction triggered by tumor bone metastasis, reduce bone destruction, and lower the risk of pathological fracture. Commonly used drugs include pamiphosphate, zoledronic acid, ibandronic acid and so on. 3. Dessumab: Dessumab is a kind of targeted drug, which can inhibit osteoclast activity by blocking the RANKL signaling pathway and effectively inhibit osteolytic reaction. Bone metastasis of malignant tumors can be treated with radiotherapy, external fixation therapy, surgery, etc. It is recommended that patients go to the hospital as soon as possible, and ask professional doctors to evaluate their conditions and adopt scientific treatment.