Depending on whether the gout patient follows the doctor’s instructions and the uric acid control and other factors, there may be a difference between the first and the second attack, and there will be some differences in the location and pain level of the two occurrences. Gout is mainly due to uric acid salt in the joints and surrounding soft tissue deposition, aggregation caused by inflammation, the common symptoms of severe joint pain and joint swelling, gout acute attack at night and the onset of disease suddenly, the majority of patients with the first attack as a single joint involvement, the nature of the pain for the cut-like or tear-like, progressively aggravated. After the first attack of gout patients, if timely and standardized medication, dietary management and other treatments, can reduce the number of gout attacks; if the patient does not undergo formal treatment, the second and subsequent attacks may occur in the location of the attack, multi-joint development, pain intensification and prolongation of the duration of the attack and so on. Gout patients should go to the rheumatology and immunology department and other related departments in regular hospitals and actively cooperate with doctors for standardized treatment.