Anti-SSB antibodies are one of the more important autoantibodies in rheumatic immune system diseases. Positive anti-SSB antibodies suggest the possible presence of dry syndrome or systemic lupus erythematosus. When a woman with positive anti-SSB antibodies becomes pregnant, the fetus may be greatly affected, and fetal death and fetal edema may occur during pregnancy. It is important to have regular maternity checkups during pregnancy and to use medications for treatment during pregnancy. The specific medications need to be adjusted according to the condition of the pregnant woman as prescribed by the doctor. It is generally safer to get pregnant when the condition is stable, but it is important to keep an eye on yourself and your fetus during pregnancy under the joint guidance of your obstetrician and rheumatologist, and to intervene promptly if adverse symptoms are detected.