Possible causes of coughing up blood in sputum at night include acute and chronic bronchitis, tuberculosis, and lung cancer. The treatments are different, including anti-infection treatment, anti-tuberculosis treatment, surgical treatment, radiotherapy, targeted therapy and so on. 1. Acute and chronic bronchitis: bronchitis hemoptysis is usually a small amount of hemoptysis, so usually only symptomatic treatment is needed, acute exacerbation of the main anti-infective treatment, after clarifying the bacterial infection, the choice of drugs are amoxicillin, cefuroxime and so on. When it is clear that the mycoplasma infection, you can choose azithromycin, levofloxacin and so on. You can also use some cough expectorant drugs such as bromhexine, aminoglutethimide hydrochloride and so on. 2. Tuberculosis: Tuberculosis patients need long-term regular anti-tuberculosis treatment, commonly used drugs are isoniazid, rifampicin, streptomycin and so on. Often need a variety of drugs used in combination. A small amount of hemoptysis can be taken orally some hemostatic drugs, such as aminocaproic acid, carbachol, and so on. In case of hemoptysis, intravenous hemostatic drugs such as posterior pituitary hormone should be used in time, and bronchial artery embolization can be performed to stop hemoptysis if necessary. 3. Lung cancer: most of the hemoptysis of lung cancer is small hemoptysis, so generally there is no need for hemostatic treatment, and the treatment is mainly for lung cancer itself. Patients who are eligible for surgery are preferred to undergo radical surgical resection, and after surgery, chemotherapy, radiotherapy and targeted therapy can be used in conjunction with their conditions. For patients who cannot be surgically resected, they can choose comprehensive treatment, including chemotherapy, radiotherapy, targeted therapy, immunotherapy and so on. In addition to the above diseases, coughing up blood in sputum at night may also be caused by bronchial dilatation, pneumonia, pulmonary embolism and other diseases, and it is recommended that the patient go to the hospital as soon as possible to find out the cause of the disease in time, and give targeted treatment. The above medications should be used under the guidance of a physician.