Symptoms caused by sclerosis of the walls of the large arteries are mainly the result of the involvement of the relevant organs, manifested by the decline of mental and physical strength, and the thickening, lengthening and hardening of the arteries on the body surface such as the radial and femoral arteries on palpation. Aortic aneurysms, such as those of the aorta, are most common in the abdominal aorta below the opening of the renal artery. Coronary arteries mainly cause angina pectoris, heart attack and fibrosis of the heart muscle. Cerebral arteriosclerosis mainly causes cerebral ischemia, vertigo, headache, syncope or cerebral artery thrombosis, rupture and bleeding, causing cerebrovascular accidents with dizziness, vertigo and vomiting. There is also renal arteriosclerosis, which can cause pain in the renal artery and kidney area, urinary closure, and fever. Arteriosclerosis of the extremities is most common in the lower extremities, especially in the leg arteries, which can cause coldness and numbness in the lower extremities and intermittent claudication.