Thyroid nodule gene mutation, usually referred to as BRAFV600E gene mutation, which is mostly suggestive of thyroid cancer. The treatment of thyroid cancer is mainly through surgery, radioactive iodine therapy, thyroid-stimulating hormone (TSH) suppression therapy and so on. 1. Surgery: Surgery is the first choice for thyroid cancer, which can be performed by total thyroidectomy, subtotal thyroidectomy and lymph node dissection in the neck. 2. Radioactive iodine treatment: I131 treatment is usually performed 6-12 weeks after surgery, which can remove the remaining thyroid tissue, and residual tumor cells. 3. Thyroid stimulating hormone suppression therapy: thyroid cancer patients who have undergone near-total or total resection should take thyroxine tablets or levothyroxine for life in order to prevent hypothyroidism and suppress TSH. common adverse reactions include rapid heartbeat or arrhythmia, profuse sweating, etc. Once they occur, they should inform the doctor and handle them appropriately. It is recommended to visit the hospital in time to avoid delay when a thyroid nodule gene mutation is detected.