White bumps in the coronal groove may be related to pearly rash, eczema, prepuce glans and sebaceous cysts, which can be treated by topical ointment and oral medication, incision and drainage surgery. 1. Pearl Rash: Pearl Rash refers to pearly penile papules, a skin condition that occurs on the coronal edge of the penis and the coronal sulcus, and may be related to local irritation and physiologic developmental variants. It will form white bumps on top of the skin, and does not require treatment in the absence of clinical symptoms. 2. Eczema: Eczema is an inflammatory skin disease that causes white bumps or red herpes on the skin, accompanied by itching and pain. Eczema can be treated with Dexamethasone Acetate Cream and Trimethoprim Econazole Cream, or with oral Cetirizine Hydrochloride Capsules if the symptoms are severe. 3. Foreskin glansitis: Foreskin glansitis is caused by long-term bacterial infection of the foreskin, which will lead to the appearance of many small red bumps on the top of the foreskin and penis, accompanied by itching and pain. It can be treated by medicines such as erythromycin ointment, cefixime dispersible tablets and amoxicillin capsules. 4. Sebaceous cysts: Sebaceous cysts are caused by the blockage of the sebaceous gland opening, which will lead to the secretion inside can not be discharged normally, and will also form white bumps. It can be treated by incision and drainage surgery. Patients must go to the hospital in time for examination, and the doctor will treat according to the individual’s condition, and also keep the local hygiene and cleanliness. The application of the above drugs must be under the guidance of a specialized physician.