Creatinine and urinary protein are not directly related, but the presence of urinary protein for a long time will affect kidney function. Many chronic kidney disease patients mainly have urine protein at the early stage of the disease, and may have no obvious discomfort in other parts of the body. In fact, urine protein is not so simple, it may be a sign of kidney problems. Kidney is the excretory organ of human body, if there is a problem here it will affect the human body and even fatal. The occurrence of chronic kidney disease and protein in urine is not only a large loss of nutritional protein, but also aggravates the damage of glomeruli. In addition, under normal circumstances the glomeruli filter out small molecules of protein, but all can be reabsorbed back into the bloodstream by the renal tubules, long-term urine protein will make the renal tubules overloaded for a long period of time, which will cause damage to the renal tubules. Research has confirmed that urinary protein is an independent risk factor for uremia, and the greatest harm lies in poisoning the kidneys and accelerating the progression of the condition to uremia.