Surgical treatment of refractory epilepsy

  Epilepsy is a common disease, and there are about 10 million people with epilepsy in China. Of these, 70-80% can be controlled with reasonable drug therapy, but 20-30% are still poorly controlled with drugs. Epilepsy surgery focuses on refractory epilepsy that is difficult to control with medications. The indications for epilepsy surgery include: 1) a clear diagnosis of epilepsy; 2) frequent and severe seizures that affect the patient’s daily life and work; 3) refractory epilepsy with a disease duration of more than 2 years and no significant remission by systematic and regular drug therapy; 4) patients or family members with a strong desire for treatment; 5) patients without serious systemic diseases who can tolerate surgery; 6) secondary epilepsy with a clear cause.  Surgical treatment of epilepsy is a treatment method that uses surgical procedures to remove the lesion, block the epileptic transmission pathway or reduce the excitability of the cortex, so as to reduce or eliminate seizures. There are several surgical options for epilepsy, the most ideal and effective of which is epileptic focal resection, which is one of the internationally respected methods, but the epileptic foci must be accurately localized before surgery. The epilepsy localization requires a comprehensive assessment, and the main preoperative tests include MRI, functional MRI, EEG (long-range video EEG detection,, magnetoencephalography, PET, etc. In addition, for those who have difficulty in localization, intracranial electrode implantation can be performed surgically followed by video EEG detection. The efficacy of epilepsy surgery is certain. In general, after strict preoperative evaluation and reasonable surgery, most of the so-called “refractory epilepsy” can be treated or even cured.