Post-infarction confusion is a manifestation of post-stroke cognitive dysfunction and can be rehabilitated through treatment, which includes medication and rehabilitation training of cognitive function. Drugs mainly include cerebroprotective drugs such as butalbital, edaravone and eurefranil, cerebral metabolic fugitives such as piracetam and olacetam, and neurotrophic drugs such as vitamin B1, vitamin B12 and methylcobalamin. In addition, patients with significant symptoms of confusion should use donepezil and memantine to improve cognitive function. Rehabilitative training includes memory, orientation and calculation training. The patient’s memory function can be improved by reciting words and numbers, and the patient’s orientation can be improved by repeatedly asking for locations and directions. Simple calculation problems can also be done to improve the patient’s calculation ability. With the above treatments, most of the confusion symptoms of brain infarction patients can be improved.