Patients with multiple small mesenteric lymph nodes need to go to the hospital as soon as possible to complete relevant tests to clarify the cause and then give appropriate treatment, including blood tests, C-reactive protein and abdominal ultrasound. If a bacterial infection is considered, antibiotics should be given, such as cephalosporin or penicillin, and sometimes anti-anaerobic drugs such as metronidazole and ornidazole. If it is considered to be caused by viral infection, it needs to be treated with antiviral drugs, and at the same time, it can be treated with traditional Chinese medicine, which is more effective. Sometimes it is caused by lymph node metastasis of malignant tumor, which needs to be clarified by blood test, tumor marker, abdominal enhancement CT, and colonoscopy. If the disease is caused by lymph node metastasis, radical tumor resection, lymph node dissection, chemotherapy, targeted drug therapy and Chinese medicine treatment should be given later.