The composition of Bayxin Tong is nifedipine controlled release tablets, the composition of Nosinto is sacubitril valsartan, the composition of betalactam is metoprolol, the combined use of the three drugs plus spironolactone, the blood pressure is still high, may be due to the blood pressure is more stubborn, can be added to the doctor’s prescription terazosin. The main effect of nifedipine controlled release tablets is to inhibit calcium ion inward flow, sacubitril valsartan can inhibit angiotensin II receptor, metoprolol can reduce heart rate, spironolactone has the effect of diuresis to reduce the blood volume, the combination of four kinds of drugs is still high blood pressure level, considered refractory hypertension, can be added to alpha-blocker terazosin under the guidance of the doctor, to increase the effect of lowering blood pressure. Refractory hypertension, in the adjustment of drug treatment program at the same time, we should pay attention to the patient’s factors that cause elevated blood pressure, focusing on secondary hypertension related to the examination, to clarify whether there are other reasons for elevated blood pressure, to treat the factors that elevate blood pressure. Patients with refractory hypertension should go to the hospital in time, and can be treated under the guidance of physicians.