Acute appendicitis cannot be vaccinated. There are contraindications to vaccination, including various acute stages of inflammation. Acute appendicitis, if it is in the acute period of the disease, the patient will have abdominal pain, abdominal distension, fever and other symptoms, which may lead to discomfort in various organs of the body after vaccination. Moreover, during acute appendicitis, it is often necessary to use some anti-inflammatory drugs, and these drugs and the vaccine may also interact with each other. During acute appendicitis, the inflammation should be controlled first, usually after the inflammation is controlled and the medication is discontinued for a week before the vaccine can be administered, and before the vaccine is administered, the patient should go to the hospital for counseling and relevant examinations.