Meige syndrome, also known as idiopathic blepharospasm-oromandibular dystonia syndrome, is a rare type of segmental dystonia disorder characterized by blepharospasm and abnormal oromandibular dystonia. Meige syndrome usually develops between the ages of 30 and 60, and is more common in women, with a male-to-female ratio of approximately 1:3. Meige syndrome is classified into three types according to the clinical manifestations: blepharospasm, blepharospasm-oromandibular dystonia, and orofacial dystonia, among which blepharospasm combined with orofacial dystonia is regarded as the complete type of Meige syndrome. Bilateral blepharospasm is the most common first symptom of the disease, eyelid weakness and ptosis are also common, and in a few cases, abnormal tension in the lower face is the first symptom. In some patients, the disease starts in one eye and gradually involves the opposite side, with symptoms such as eyelid irritation, dry eyes, photophobia and increased transients, followed by tonic or clonic contraction of the orbicularis oculi muscle until both eyes are completely closed, and the patient can accomplish visual dependent tasks such as watching TV, reading newspapers, walking, etc. In severe cases, functional blindness may occur, and the patient may lose the ability to live independently. Some patients progress gradually from blepharospasm downward, the most common involvement of the lower face and masticatory muscles, manifested as jaw opening – closing, pouting, the lower part of the mouth and lower jaw rhythmic or tremor-like movements, blepharospasm combined with mouth opening, pouting, the lower part of the twitching leads to the production of “strange looks”. Involvement of the glossopharyngeal, laryngeal and respiratory muscles may manifest as paroxysmal tongue muscle spasm, dysphagia, spasmodic dysphonia and dyspnea. Involvement of upper and lower limbs can be manifested as postural tremor, writing spasm, hand and foot twitching. One of the characteristics of the disease is the “Tricks” phenomenon, i.e., the patient whistles, sings, looks down, chews gum, touches the periorbital area, or bites a toothpick, and the symptoms are completely relieved, and other symptoms, including those of touching the cheeks, lips, or the back of the head, are also dramatically reduced. In addition to blepharospasm and orofacial dystonia, Meige syndrome with mood disorders is more common, with a higher incidence of depression and, in some cases, anxiety with depression, which needs to be differentiated from primary psychiatric disorders. Pharmacological treatment for Meige syndrome includes anticholinergics, GABA-enhancing drugs, antiepileptics, and antipsychotics. When a single drug is ineffective, a combination or alternation of drugs may be considered to improve efficacy and minimize adverse effects. Currently, botulinum toxin A injection under electromyography guidance is the first choice of treatment for patients with Meige syndrome, and deep brain stimulation (DBS) can be considered for patients with ineffective botulinum toxin A injection or severe symptoms that significantly affect the quality of life.DBS is a safe and effective treatment for Meige syndrome, and brings a better treatment to patients with refractory Meige syndrome. DBS is a safe and effective treatment for Meige syndrome, bringing new hope to patients with refractory Meige syndrome.