Positive BCG pure protein derivative skin test suggests BCG vaccination or tuberculosis infection, if the active stage of tuberculosis need to follow the doctor’s advice to use isoniazid and other drugs, if the previous infection of tuberculosis, tuberculosis activity can be regularly observed, if the performance of the BCG vaccination, imaging tests to rule out the tuberculosis, then there is no need for treatment. 1. active tuberculosis: BCG pure protein derivative skin test mostly shows strong positivity, accompanied by cough, sputum, night sweats and other symptoms, chest CT and other signs of tuberculosis infection can be detected, a clear diagnosis of the need to strictly follow the medical advice, the use of isoniazid, rifampicin and other anti-tuberculosis treatment. 2. Previously infected with tuberculosis: If you have been infected with tuberculosis, but there is no active manifestation at present, you may also have a positive skin test for pure protein derivatives of BCG, but there is no need to treat it after it is confirmed through examination, and regular monitoring is sufficient. 3. BCG vaccination: it may be manifested as general positive or moderate positive, not accompanied by signs of infection, and the doctor needs to rule out tuberculosis infection with the combination of symptoms and examination, and no treatment is needed. Positive skin test for pure protein derivatives of BCG needs to be determined by the doctor in conjunction with the symptoms and examination, and it is recommended to consult a doctor for clarification in a timely manner.