Gastric cancer patients will mostly end up with painful symptoms, but the cause of death may be having multiple organ failure, severe malnutrition, gastrointestinal bleeding, and so on. Gastric cancer is a common malignant tumor of the digestive system, which can be caused by factors such as heredity, Helicobacter pylori infection, and poor dietary habits. Patients with advanced stage are often accompanied by more serious pain in the primary site of tumor and metastatic foci, and often need to be treated symptomatically by fentanyl, morphine and other drugs, which should be applied under the guidance of doctors. With the progression of the disease, patients with advanced stage often have multiple distant metastases, which often complicate multiple organ failure. At the same time, the side effects of tumor growth and various treatments can cause serious consumption of patients, leading to malignant disease. Some patients may also have digestive bleeding and hemorrhagic shock. All these factors can lead to death of stomach cancer patients. It is recommended to consult doctor in time and carry out individualized treatment under doctor’s guidance to reduce pain and improve quality of life in advanced stage of gastric cancer.