After cholecystectomy with erosive gastritis, bile reflux, Helicobacter pylori positive can follow the doctor’s instructions to take aluminum thioglycollate, domperidone, omeprazole and other medications to protect the gastric mucosa, reduce bile reflux, and at the same time, eradication of Helicobacter pylori. After cholecystectomy, the contraction function of pyloric sphincter decreases, and bile refluxes into the stomach, which stimulates the gastric mucosa and leads to or aggravates gastric mucosal erosion, and the infection of H. pylori also aggravates the inflammatory reaction of the gastric mucosa. You can follow the doctor’s instructions to take drugs such as aluminum sulfate to protect the gastric mucosa, reduce the stimulation of the gastric mucosa by bile, and relieve inflammation; you can also take domperidone, mosapride and other gastric dynamics drugs to promote gastric peristalsis, accelerate gastric emptying, and reduce the reflux of bile; H. pylori is positive and you can take omeprazole, amoxicillin, clarithromycin, bismuth pectin and other medications to eradicate, and improve inflammatory reactions of the gastric mucosa. After cholecystectomy bile reflux accompanied by erosive gastritis, Helicobacter pylori infection should be timely medical treatment, under the guidance of the doctor, do not blindly take drugs. In addition, patients should usually pay attention to a light diet, eat more millet porridge and other easily digested and absorbed food, avoid greasy food such as french fries and French fries, do not drink alcohol, and eat small meals.