Waking up at night with a thumping heart may be due to the presence of hyperthyroidism, coronary artery disease and other reasons, according to the cause of propylthiouracil, aspirin and other drugs or interventional surgery to cope with the way. 1. Hyperthyroidism: excessive secretion of thyroid hormones can make the patient’s heart beat faster, waking up at night, the treatment is generally taken to methimazole, propylthiouracil and other drugs, the more serious can also be used in sub-total thyroidectomy surgery and other ways of treatment. 2. Coronary heart disease: myocardial ischemia due to atherosclerosis of the coronary arteries of the heart, nighttime occurrences can wake up with palpitations, treatment can be taken orally antiplatelet drugs such as aspirin, nitroglycerin, metoprolol and other drugs, or percutaneous coronary intervention. The above drugs need to consult a physician before use, not blindly self-medication. There may be other reasons for waking up with a thumping heart at night, so you can go to the hospital for a relevant examination and take corresponding measures.