The patient wiped his ass after a little blood on the handkerchief, the first consideration is certainly anal disease, the most common situation is to get hemorrhoids or anal fissure, got one of these two common anal disease, it is possible to appear the above situation. Specifically in the end is anal fissure, or hemorrhoids, the biggest difference between the two lies in the patient defecation, whether the anus has a feeling of intense pain, as follows: 1, anal fissure: if it is to get anal fissure, the patient will have a feeling of intense pain when defecating, and this feeling can not be relieved for a period of time after the defecation, often the patient is also accompanied by a dry stool, defecation laborious. 2, hemorrhoids: if it is hemorrhoids, often the Painless blood in the stool, in addition to wiping the buttocks of the toilet paper with a little blood, there is no longer any other symptoms, this point should be noted and anal fissure identification. If you are not sure, the patient can go to the regular hospital anorectal department, improve the relevant examination, by experienced doctors to make a diagnosis, guide the treatment.