Wound scabbing and blistering may be related to over-tightening of sutures during skin closure, or it may be caused by drug allergy, secondary infection and other reasons. 1. Tight sutures: When a wound is too big and needs to be sutured, if the sutures are too tight, it will easily lead to the obstruction of the blood supply of the skin at the wound site, which may cause the wound to be descaling and blistering. 2. Drug allergy: especially for the allergic body, may be allergic to the wound skin area of the drug, such as the application of medical alcohol disinfection or povidone-iodine disinfection allergy, may cause wound scab blistering. 3. secondary infection: in the process of wound healing, if you do not pay attention to good daily care, resulting in wound local skin secondary infection, may cause wound scab blistering, may also be accompanied by obvious pain, itching and other symptoms. Wound scabs and blisters may also be caused by other reasons, it is recommended to consult a doctor as soon as possible to diagnose the cause of the disease, and then give targeted treatment and conditioning.