Finger belly wrinkled with vertical lines may be associated with progressive finger palm keratoderma, may also be associated with prolonged immersion. 1. Progressive angular dermatosis of the fingers and palms: also known as housewife dermatitis, lack of fat hand eczema, is due to long-term repeated cleaning led to the palm of the hand parts of the skin dry, cracked, superficial flaking of a skin disease. Mainly occurs in the female after puberty, manifested as dry skin, rough, local redness and flaking, there can be thickening of the stratum corneum and cracking, cracking can be painful, no systemic manifestations. 2. Physiological factors: prolonged immersion will lead to changes in the osmotic pressure of the skin of the hand, the skin stratum corneum absorbs water and expands, resulting in the phenomenon of wrinkles, which is a relatively common physiological phenomenon. Due to the existence of some differences in clinical manifestations, the specific circumstances need to ask the doctor for an interview.