Diffuse echo abnormalities of the thyroid gland can be seen in a variety of thyroid diseases, such as Hashimoto’s thyroiditis, Graves’ disease, subacute thyroiditis, etc., can not be diagnosed based on the indicators alone, should be combined with other tests to clarify the diagnosis of different diseases with different treatment methods. 1. Hashimoto’s thyroiditis: For patients with Hashimoto’s thyroiditis, no special treatment is needed when the thyroid function is normal and the clinical symptoms are not obvious, and regular checkups are sufficient; abnormal thyroid function, significant enlargement of the thyroid gland or pain, and compression symptoms require treatment, such as thyroid hormone replacement therapy, surgery, and so on. 2. Graves’ disease: patients need to take antithyroid drugs such as methimazole and propylthiouracil as prescribed by the doctor, and radioactive iodine treatment or surgery is also available. 3. Subacute thyroiditis: it is a self-limiting disease and can be treated symptomatically with anti-inflammatory and pain relief. Diffuse echogenicity of the thyroid gland requires timely medical attention to identify the cause and treatment.