Pain in advanced stage of liver cancer is usually not regular, some patients will have persistent pain, and some patients may have intermittent pain. When liver cancer is in the advanced stage, the tumor will seriously invade the liver, resulting in liver damage and strong stimulation to the patient’s liver periphery, because there are a large number of nerves in the liver periphery, so the patient will suffer from severe pain. However, this kind of pain usually has no regularity, some patients with serious symptoms will have continuous pain, while some patients will have intermittent severe pain. Patients with advanced liver cancer also have fever, swelling of lower limbs, fatigue and coma. For patients with advanced liver cancer with more serious pain, they can take painkillers such as morphine sulfate extended-release tablets under doctor’s instruction to relieve pain. Patients with advanced stage of liver cancer should consult doctor for timely examination and treatment when any physical discomfort occurs, so as to reduce the pain brought by the disease.