Antinuclear antibody 1:320 may have serious implications for pregnancy. Antinuclear antibody 1:320 indicates strong positivity of antinuclear antibody, and the patient may have autoimmune disease such as systemic lupus erythematosus (SLE), and pregnancy is generally not recommended. Pregnancy will aggravate the condition of SLE and cause endothelial lesions in blood vessels, affecting the blood circulation of the placenta, etc. Pregnancy is also likely to lead to malformations of the fetus, miscarriages, and other adverse conditions. If anti-nuclear antibody is found to be positive, anti-double-stranded DNA antibody as well as anti-SM antibody should be done again to clarify whether there are immune diseases such as SLE. If the primary disease is not controlled, it may affect the growth and development of the fetus. If the patient is already pregnant, termination of pregnancy should be considered if the disease is serious; if the disease is mild, standardized treatment can be carried out to alleviate the disease and reduce the risk. It is recommended that patients go to the hospital in time for consultation and active treatment, and it is not recommended to prepare for pregnancy before cure, so as to avoid adverse effects on the pregnant woman and on the fetus.