When emphysema patients have wheezing, shortness of breath, chest tightness and other respiratory difficulties, that is, the acute exacerbation period, this time should take appropriate comprehensive measures to alleviate the problem, should be given a continuous low-flow oxygen inhalation, the oxygen concentration can be within 30%, the oxygen flow rate is controlled in the 1-2L per minute, and glucocorticosteroids are given to alleviate the symptoms, such as the choice of methyl prednisolone, prednisone, budesonide, can be given in the form of intravenous drip as well as nebulized inhalation. The glucocorticosteroids should be given in the form of an intravenous drip as well as by nebulized inhalation. Bronchodilators such as tiotropium bromide, terbutaline and salbutamol aerosol are also given. Expectorants such as brown colloid and carbocysteine oral solution are given in case of more sputum. Sensitive antibiotics such as cephalosporin third generation drugs as well as quinolones should be given in case of co-infections and may also be combined with macrolides.