Whether target drugs are needed after total nephrectomy for kidney cancer should be chosen according to the patient’s condition and degree of deterioration. Kidney cancer is a kind of malignant tumor originated from renal tubular epithelium, and patients may have manifestations such as hematuria, pain, abdominal mass and so on. For early stage renal cancer without metastasis after total excision, targeted drugs are usually not needed. If patients with progressive or advanced kidney cancer undergo tumor reduction or palliative surgery, or have recurrence or metastasis after surgery, they need to use targeted drugs for adjuvant treatment. Besides, kidney cancer patients can also receive adjuvant treatment through radiotherapy and immunotherapy to alleviate their condition and improve their quality of survival. If kidney cancer is suspected or diagnosed, it is recommended to go to regular hospitals for a comprehensive assessment of the condition, follow the doctor’s instruction to cooperate with the treatment, choose the appropriate treatment plan to improve the prognosis of the patient, and follow the doctor’s instruction to review the condition after surgery to avoid delay. Please strictly follow the doctor’s prescription for medication, and do not use medication on your own.