Upset stomach after taking Duloxetine is most often caused by an adverse drug reaction or overdose. Duloxetine can be used to treat depression or anxiety disorders. Duloxetine can cause irritation to the gastrointestinal tract, causing nausea, diarrhea, constipation and other gastrointestinal reactions, causing symptoms of an upset stomach. It can also cause other adverse reactions such as dry mouth, drowsiness, constipation, decreased appetite, and excessive sweating. It is contraindicated when you are allergic to this drug or have uncontrolled narrow-angle glaucoma disease. Combination of this product with monoamine oxidase inhibitors is prohibited. Patients who change the dosage on their own may experience an acute overdose of the drug, which can also cause gastrointestinal irritation, causing vomiting as well as stomach pain and other symptoms of an upset stomach. Patients who have taken Duloxetine upset stomach should go to the hospital in time to consult the doctor and choose the appropriate method of treatment.