Paliperidone must be taken in the morning generally to ensure the effectiveness of the medication. Paliperidone is an antipsychotic medication used primarily in the acute and maintenance phases of schizophrenia, often taken once a day in the morning, the starting dose does not need to be titrated, and is often taken in the morning to ensure that the medication is effective, and the effects tend to last throughout the day, and it is easier to take. Some adverse reactions may occur after taking the medication, such as metabolic changes, seizures, headache, insomnia, tachycardia, and difficulty swallowing, etc. If the adverse reactions are significant, the medication must be discontinued promptly. Paliperidone should be taken with care that it is contraindicated for those who are allergic to paliperidone, risperidone or any of the components of the drug. It should not be used by pregnant and lactating women. If the drug is taken along with other medications, there is a possibility of drug-drug interactions, so be sure to consult your doctor first. In addition Paliperidone should be taken under the guidance of a professional doctor, and should not be taken on its own.