The specific time of side effects of bone cement is not uniform, some patients appear at the time of filling, some patients appear in 1~3 years, and some patients do not have side effects, depending on the patient’s own situation. Bone cement is a kind of bone adhesive, the main ingredient is polymethyl methacrylate, which is commonly used in orthopedic surgery, and can be used to fix artificial joints or repair bone defects. Its side effects may include causing high pressure in the bone marrow cavity when filling, causing fat particles to enter blood vessels and cause embolism, or causing the body’s rejection reaction to loosen the bone cement. However, these side effects are relatively rare in clinical practice. The time of the appearance of bone cement is not necessarily the same, some patients will have side effects at the time of filling, and some patients will have side effects in 1~3 years, or not. There is individual variability in clinical practice. With the development of technology, most of the patients are generally do not have side effects. After surgery, patients should eat more protein-rich foods, perform functional exercises under the guidance of the doctor, and pay attention to regular review. If there are symptoms of discomfort, go to the hospital in time for follow-up.