Demyelinating changes in the white matter of the brain can be mild or severe, and the severity of the condition varies depending on the individual patient. If a patient has white matter demyelinating changes on imaging and has no clinically significant symptoms, the condition is generally less serious. If the patient has obvious clinical symptoms and the white matter demyelination is caused by various diseases such as multiple sclerosis and optic neuromyelitis optica spectrum disorders, the condition is relatively serious and requires prompt treatment. Clinically found cerebral white matter demyelination changes, it is recommended to regular hospitals, follow the doctor’s instructions for timely treatment, to avoid the impact on the body.