Melanin around the mouth, which may be caused by keratitis, sunburned skin, internal diseases, etc., can be improved or removed with the help of medication and medical aesthetic treatments. 1. Keratitis: Keratitis patients will have repeated redness, swelling, pain, cracking of the corners of the mouth, such as patients often lick the affected area, tearing the scabs, do not comply with the doctor’s instructions to use medication, etc., which may lead to the occurrence of melanin precipitation around the mouth. Such patients can use erythromycin ointment, clotrimazole ointment and other drugs to help improve the keratitis, to assist in removing the corners of the mouth blackened; serious cases can use fractional laser, picosecond laser, chemical peeling and other medical treatment to help improve the symptoms. 2. Sunburn: excessive ultraviolet radiation may lead to skin darkening, for patients with more obvious sunburn around the lips will appear around the mouth melanin deposits further deepening, such patients can help prevent further darkening around the lips by strengthening sunscreen. Symptoms of obvious people can use the cumulonimbus cream ointment, hydroquinone cream, vitamin A cream, vitamin E cream, vitamin C essence, etc. for local application, to help remove melanin. 3. Internal medicine diseases: a variety of adrenal-related diseases and liver diseases can lead to melanin metabolism disorders in the patient’s body, which may cause the patient to appear multiple parts of the melanin precipitation, which occurs around the lips may cause the patient to appear around the mouth melanin precipitation obvious performance. This type of patient can be helped by glucocorticoids such as prednisone and other drugs to treat the primary disease, so as to improve the darkening around the lips. If the black pigmentation around the mouth persists without relief, it is recommended to consult a doctor in time to clarify the cause of the disease and treat it under the guidance of the doctor, and do not use medication on your own.