The causes of acute exacerbation of chronic kidney disease include inappropriate use of drugs, infection, complication of other diseases and poor lifestyle. 1. Inappropriate use of drugs: Mostly considered because patients take nephrotoxic drugs, such as vancomycin, cephalosporin and other aminoglycoside antibiotics, as well as ibuprofen, indomethacin, diclofenac and other non-steroidal anti-inflammatory drugs. 2. Infection: If patients are infected by bacteria, virus or other pathogenic microorganisms during the period of illness, it is easy to aggravate chronic kidney disease. 3. Complications of other diseases: clinically, it is mostly seen in low blood pressure, heart failure, hypertension, coronary heart disease, hyperglycemia and so on. 4. Poor lifestyle: if patients often stay up late at night and have too much psychological pressure, it is easy to cause abnormal secretion of hormone levels, followed by drinking alcohol, smoking and so on. Usually, after standardized treatment in time, chronic kidney disease will not affect the normal life expectancy, and the disease can be controlled to improve the quality of life. To summarize, patients need to go to the hospital in time, strengthen their daily life management and cooperate with doctors for active treatment.