Postherpetic neuralgia (PHN) is a sequela of acute herpes zoster. Although most patients with herpes zoster resolve on their own, a significant number of older adults develop intractable pain. Therefore, PHN is one of the most persistent pain disorders in the middle-aged and elderly population. Overall, the incidence of PHN is proportional to age, 49% in 50-59 years, 65% in 60-69 years, and 74% in 70-79 years. The duration of the disease can be as short as 1-2 years or as long as 10 years, and without effective pain control methods, the history of the disease is usually 3-5 years. Treatment The goal of postherpetic neuralgia treatment is to control daytime pain and improve functional activities; to relieve nighttime pain and improve sleep. Medication Medication is still the most basic and commonly used method. Pharmacological treatment of postherpetic neuralgia has three objectives: analgesia, reduction of depression and anxiety, and reduction of insomnia. The responsiveness of PHN to drugs is clinically different from that of AHZ, so many commonly used analgesic drugs are not effective, while commonly used narcotic analgesics, hormones, and some NSAID drugs have a pain-relieving effect on some patients. Because chronic pain syndromes are associated with some degree of depression and anxiety and insomnia, sleeping pills, sedatives, antidepressants, and anticonvulsants are often used as analgesic adjuncts. The choice of medication for the treatment of postherpetic neuralgia should be based on the characteristics of the specific patient’s condition, taking into account other factors such as ethnicity, lifestyle, and allergy history, with a reasonable mix and combination of medications to reduce adverse effects, and timely adjustment of the dosing regimen based on treatment response. Since most of the patients with PHN have severe pain, the clinical response to drug therapy varies greatly among individuals, and a reasonable combination of drugs should be selected according to the length of medical history, the nature of pain and previous medication history to achieve the purpose of pain relief. 2.Nerve block According to our preliminary clinical experience, regional nerve or nerve root injection is the most effective method to relieve severe pain in PHN patients. Regional nerve block for PHN includes local infiltration drug injection, nerve trunk block, paravertebral nerve root and sympathetic ganglion and local intravenous drug injection. If necessary, radiofrequency of the dorsal root ganglion is performed to directly block nociceptive transmission. However, it is important to achieve accurate positioning and technical operation in order to ensure the effect of treatment.