Cholestasis can cause itchy skin, but itchy skin caused by other internal diseases and dermatologic diseases cannot be excluded. Cholestasis will cause bile acids, bilirubin, etc. will flow back into the blood system, which can stimulate the sensory nerves of the skin, and then appear itchy skin symptoms, but this situation is only limited to its own liver and gallbladder disease, if there is no liver and gallbladder disease, should be considered whether to suffer from dermatological and other internal diseases, so as not to delay the treatment of the condition, aggravate the condition. If the symptoms of itchy skin are not relieved, or accompanied by other symptoms, you should go to the hospital in a timely manner to improve the relevant examination, to clarify the cause and then give targeted treatment.