Syphilis in sexually transmitted diseases is very complex, at present, in addition to AIDS is syphilis, one of the manifestations of the interpretation of the laboratory report, syphilis laboratory report is very simple, is the RPR and TPPA, but the dynamic monitoring of the emergence of the trend is very learned. Typically, patients with syphilis will be positive for two main types of antibodies, one for non-syphilis spirochetes and one for spirochete-specific antibodies. The former is detected by RPR or TRUST and the latter by TPPA or TPHA. Once infected with syphilis, both will be positive for RPR and TPPA successively. How to look at the syphilis test results, RPR is generally to see the titer, one to several, if it is the original times called 1:1, and then is 1:2, 1:4, 1:16, 1:32 ……, are all times the relationship. TPPA results are generally a positive, but also can be quantitatively to do its titer. In fact, we must look at the RPR in order to determine whether the patient is currently suffering from syphilis, the duration and condition of the infection, and the regression of syphilis after treatment. For example, if a patient with syphilis has an RPR of 1:128 before treatment, and the RPR becomes 1:8 after treatment, or is negative, it means that there is a good therapeutic effect. It is common to see separate TPPA-positive, RPR-negative labs in the clinic. If there are people who have TPPA first, infected with syphilis, and soon do the test, TPPA is positive, RPR may be negative, but soon RPR will also become positive, there is another situation, because TPPA will always persist, so this time TPPA only indicates a positive, indicating infection, the observation indicators must look at the RPR. if RPR is negative, and after a period of time, the retest is still negative, it means that the infection is the same, and it is not the case. If the RPR is negative and the test is repeated after a period of time, it means that the person has been infected with syphilis, had it in the past, and is now cured; if the RPR is positive and the TPPA is positive, it means that the person is most likely to be suffering from syphilis now. But there are some people, either after treatment, or without treatment, RPR titer down to a certain level, 1:1, 1:2, 1:4, down to this level when it does not fall, no matter how much treatment, repeat many times different programs of treatment, but also has been maintained low titer positive, is the so-called serofixation phenomenon. Whether there is syphilis or not, whether it is infectious or not, this needs to be considered carefully. In principle, if it is after regular anti-syphilis treatment, the syphilis pathogen is cleared from the body, even if the indicator is positive, it does not indicate infectiousness. For this type of patient, if the drug dose is insufficient or the treatment is irregular, a course of treatment should be made up; a comprehensive physical examination should be carried out, including neurological and cerebrospinal fluid examination, in order to detect asymptomatic neurosyphilis and cardiovascular syphilis at an early stage. HIV testing should be done when necessary. Strict regular observation, including general physical examination and serologic follow-up. If the titer tends to rise, treatment should be repeated. Sometimes a low RPR titer is positive and a TPPA is positive at the same time, and such an indicator sometimes does not mean that you are definitely getting syphilis now. If the RPR titer is very high, even dynamic monitoring is still rising trend, TPPA positive, this situation confirms that you are suffering from syphilis, and just infected with syphilis for a short period of time. The lab results should also be considered for false positives. Certain immune disorders, tumors, or geriatric conditions can cause false positives, as well as physiological conditions, such as pregnancy, where false positives for syphilis can occur, and the RPR titer is generally not high. There is a lot of confusion in this area, which involves the harmony of the family, and it is really important to read the results of the laboratory tests carefully, and to consult with experts.