Both high tPSA and fPSA are not necessarily cancerous, they may be prostate cancer, or they may be the result of benign prostate disease and operations involving the prostate. PSA is a prostate-specific antigen. tPSA (total PSA) is the total value of PSA in serum, the one that exists in combination with proteins and so on is called complex PSA (cPSA), and the PSA that exists freely is fPSA. generally, the normal value of tPSA is <4 ng/ml, fPSA should be <0.8 ng/ml, and fPSA/tPSA should be <0.25. PSA is found in the epithelial cells of the prostate ducts. When the epithelial cells of the prostate ducts are destroyed, PSA is released into the blood, and tPSA and fPSA are elevated. Generally, tPSA elevated to >10ng/ml is more likely to be caused by prostate cancer, while tPSA at 4~10ng/ml may be caused by prostate cancer, or may be caused by benign diseases such as prostatitis, prostate hyperplasia and other manipulations such as prostate massage, surgery, etc., and at this time, it can be further differentiated according to fPSA/tPSA, and fPSA/tPSA <0.15 is The possibility of prostate cancer is high. Therefore, high tPSA and fPSA may be caused by prostate cancer, or it may be caused by benign prostate diseases and operations such as prostate massage. It is recommended to consult a specialist for further identification based on the fPSA/tPSA ratio, and if necessary, follow the doctor's instructions to perform prostate imaging, pathology and other examinations to clarify the nature of the lesion.