Metformin Hydrochloride Extended-Release Tablets and Metformin Hydrochloride Tablets; both belong to the biguanide class of drugs, there is no such thing as “which one is more effective”. Metformin hydrochloride tablets and metformin hydrochloride extended-release tablets both belong to the biguanide class of hypoglycemic drugs, can reduce the synthesis of glucose in the liver and inhibit intestinal absorption of glucose and then play a role in lowering glucose, can be used for the treatment of patients with type 2 diabetes mellitus who are not able to control their blood glucose well only by diet control and exercise. Metformin extended-release tablets are a kind of tablets made of special extended-release materials, which can avoid rapid disintegration in the digestive tract and have a longer half-life to play a sustained hypoglycemic effect in the body; metformin hydrochloride tablets can be disintegrated rapidly in the digestive tract after taking, with a shorter half-life to reach the blood concentration quickly. Therefore, there is no such thing as “which one is more effective”. It should be noted that people who are allergic to metformin, have kidney disease, suffer from serious trauma, infections, etc. should not use metformin treatment; nausea, vomiting, diarrhea, abdominal pain, hypoglycemia, headache, fatigue, headache, and other adverse reactions may occur after the use of the drug. Patients who need to use Metformin Hydrochloride Tablets or Metformin Extended-Release Tablets for treatment should use the drug under the guidance of a doctor.