Hiccups, also known as eructations, are a clinical manifestation caused by involuntary diaphragmatic spasms. Frantic hiccups can be caused by food, medications, and central as well as peripheral neuropathy. It is often treated with non-pharmacologic as well as pharmacologic therapies. 1. Non-pharmacological therapy: a soft catheter can be inserted into the pharynx, moving the catheter back and forth to repeatedly stimulate the pharynx, stimulating the pharyngeal plexus to inhibit the transvagal nerve excitation, which can be used to treat hiccups. In addition, you can also use acupressure supraorbital nerve method, as well as tongue traction method, and extracorporeal diaphragmatic pacing method for treatment. 2. Drug therapy: (1) Gastrointestinal power drugs: these drugs can treat hiccups caused by indigestion and other factors, which can improve the coordination of gastroduodenal peristalsis and promote gastric emptying. Domperidone, mosapride, etc. are more commonly used. (2) calcium antagonists: the use of such drugs can be treated due to cerebrovascular disease can often lead to neurological hiccups, commonly used drugs such as nimodipine. (3) Antidepressants: The use of drugs such as promethazine hydrochloride can treat hiccups caused by depression. If the hiccups are not relieved, or accompanied by other symptoms, you should go to the hospital in a timely manner, to clarify the cause of the hiccups, and then follow the doctor’s instructions to give targeted treatment. The medication should be used in accordance with the doctor’s instructions.