In general, long-term use of furosemide is not recommended, spironolactone can be taken for a long time. Furosemide is a strong diuretic commonly used in clinical practice, belonging to the tabular diuretic. It is commonly used in the treatment of acute heart failure, severe edema, cirrhosis ascites and other diseases, and is generally used for a short period of time. Its contraindications are electrolyte disorders, blood volume insufficiency, furosemide allergy and so on. Adverse reactions are hypokalemia, transient deafness, blurred vision, and drug rash. Spironolactone is an aldosterone receptor antagonist, with the role of blocking the effect of aldosterone, commonly used in clinical practice to diuretic and antihypertensive, treatment of edematous diseases, anti-heart failure treatment. Contraindications are hyperkalemia, renal insufficiency, etc. Adverse reactions are gastrointestinal reactions, muscle weakness, sensory abnormalities, bradycardia and so on. If the condition requires, spironolactone can be taken for a long time. The use of furosemide or spironolactone need to be carried out under the guidance of clinicians, do not use the drug without authorization, so as not to cause adverse effects on the organism.