Hand, foot and mouth disease (HFMD) is a common infectious disease in children caused by enterovirus infection, which can be transmitted to others through direct or indirect contact. 1. Direct contact: Children with HFMD and those with hidden infection are the main sources of infection. Close contact with an infected person can cause infection, such as through contact with virus-infected hands, toys, tableware, toiletries and so on. 2. Indirect contact infection: mainly through respiratory droplet transmission, can be widely spread through the patient’s throat secretions, saliva and so on. In addition, it can also be spread through the digestive tract, such as drinking or eating virus-contaminated water, food, etc., which may cause infection. To summarize, once HFMD is diagnosed, parents should bring their children to the hospital in time, and the doctor will provide appropriate isolation treatment according to the specific condition of the child, so as to avoid cross-infection and spreading the disease to others.