The factors causing pituitary microadenomas in the brain are still inconclusive in the academic world, and the most popular one is the result of genetic mutation, but the factors causing genetic mutation are still under gradual research, among which the irradiation of radioactive substances, improper diet or medication have the most drastic effects. When a person is under the influence of unknown rays for a long time, it is easy to cause the disruption of cell decomposition structure, which will result in abnormal proliferation and eventually form pituitary microadenomas. Drug abuse, excessive mental stress, depression affecting the physiological structure may also aggravate the emergence and development of pituitary tumor, but there is no very clear statement, so it is more important to find the disease early and treat it early, the vast majority of pituitary microadenomas can be cured clinically, which is even more important.